Regenerative aesthetic biostimulation
Injectable platelet rich fibrin or (i-PRF) is a unique rejuvenation technique that uses the patient’s own blood plasma, enriched with:
- platelets (a source of healing proteins and growth factors)
- fibrin (the wound healing and regeneration matrix)
- stem cells (the conductors of our body’s own healing and regeneration molecules)
This product is injected, resulting in activation of accelerated healing and regeneration. As a result, the body’s own regenerative properties are concentrated and focused on the area of concern.
iPRF intensifies the functioning and reproduction of cells, having a gentle, gradual, yet long lasting and accumulative effect.
Of course, i-PRF results are all the more impressive when incorporated into a treatment plan with hyaluronic acid fillers, wrinkle-relaxing treatments and other skin treatments. Producing virtually no downtime, this clinic-based treatment can be used for skin and hair rejuvenation as well as trating problematic melasma and acne scars.
One of the newer applications of i-PRF is for the treatment of hair loss. It is used to reverse the hair loss in men and women as part of a multi-step treatment of the scalp that is done under local anaesthetic. It appears to 'reset' the hair follicles and reduce the impact of DHT(dihydrotestosterone) in those with Androgenetic Alopecia (pattern hair loss) and there is also growing evidence that PRP is the new 'gold standard' for Alopecia Areata.
We are excited to announce that we are also using i-PRF to treat arthritis. Clinical trials have already demonstrated reduced pain, improved function and even cartilage regrowth. We will be providing knee joint injections initially, and plan to follow patients over the following 6 months to gauge progress.
What are the results?
- New fibroblasts, collagen and elastin tissues are formed
- Skin elasticity and complexion is improved
- Pigmentation is reduced
- Hair regrowth
- Thicker hair
- Reduced pain
- Improved function / performance
- Cartilage regrowth
Based on a strong evidence base, and thanks to Dr Joseph Choukroun; the inventor of iPRF technology, we are supporting the development of this technology to further assist our patients.
Is this the same as PRP? What is the difference between iPRF & PRP?
Both PRP (platelet rich plasma), and PRF (platelet rich fibrin) are platelet based growth factor treatments that are extracted using centrifuge. iPRF is different from PRP in that there is no anticoagulant (blood thinner) added during the spin.
And here is the technical detail:
"The avoidance of clotting is physiological and is achieved through negative charge of the collecting tube to mimic the conditions within our own blood vessels (their lining is negatively charged) that prevent fibrin from creating a clot within them, thus, obtaining a platelet rich injectable fibrin. Once PRF is injected in the tissue it transforms from liquid into a gel, which not only lead to filling of voids in folds and wrinkles but also provide a powerful regenerative matrix that releases platelets’ growth factors in a physiological controlled slow manner that enhances tissue regeneration is a better way than PRP."
In addition, the enrichment of platelets in these two products is not the same. In PRP, the platelets are enriched two to four times above the physiological concentrations available in blood and there are very few circulating blood stem cells. In contrast, PRF contains all the platelets with no elimination of the powerful regenerative matrix (fibrin) in addition to another very rich source of growth factors and tissue regeneration: the circulating blood stem cells.
Why is fibrin important?
Dr Choukroun explains that Fibrin functions as a matrix that traps the platelets and controls their release of growth factors “very slowly and continuously over a time period of more than one week”.Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period of time following treatment. “It’s not the amount of growth factors that’s the most important, but it is released into the site. To treat severe infection, antibiotics can be injected drop by drop in an IV perfusion, ensuring that a stable concentration is maintained. This is the same in PRF biology—to obtain the most important function a stable concentration must be maintained. The best is a drop-by-drop infusion”
Aesthetic Regenerative Use of PRF
Platelet growth factors in a fibrin scaffold is the first response to injury observed in all human tissue. Thus, the applications of PRF for healing and regeneration is not limited only to skin. Accelerated healing, new blood vessels and proliferation of cells producing collagen (fibroblasts) have been well demonstrated in biomedical research investigating the basic functions of this regenerative products. The vast clinical applications have been well documented in the literature by peer reviewed systematic reviews, we will discuss with how PRF could be used alone or in combination with other treatment to address your aesthetic regenerative concerns from skin rejuvenation to tissue regeneration.
iPRF Hair Growth Treatment
This is an all-natural non-surgical therapeutic option for patients who suffer from hair loss or thinning. iPRF can enhance the growth of hair follicles by stimulating the stem cells and other cells in the microenvironment of the hair follicle. These special Platelet cells promote healing and accelerates the rate and degree of tissue regeneration, resulting in new hair growth and thickening of existing hair.
Is the treatment painful?
The treatment will not be painful, rather described as minort discomfort due to the application a topical anaesthetic to the skin before starting the treatment.
Is the treatment safe?
As i-PRF / PRP treatment uses your own blood cells, the risks of adverse reaction or complication are negligible.
At The Bloomfield Clinic, we use the latest technology to get the best quality of i=PRF or PRP from your blood.
Is there any downtime following treatment?
There is usually some short-term redness, swelling and minor discomfort in the treated area, which may last for a few hours. Bruising to the area is less common, but if it does occur it can be easily covered by makeup.
Most patients return to normal activities and work the next day.
Exceptionally, there is some downtime when it is used to treat the lower eyelids - here patients will experience some swelling for 36 hours. This can be hidden with sunglasses, but many will choose to spend time at home after they treat their lower lids. The impact of i-PRF / PRP on the lower lids lasts about two years and can create a phenomenal outcome.
How many treatments will I need?
This will depend on the reason for treatment. Significant skin and hair problems may need between 3 and 5 sessions for best results. These are usually given every 4 to 6 weeks.
Joint injections are given as a single treatment, with the option to repeat after a 3-month interval.
How soon will I see the results of the treatment?
Changes begin in a matter of hours and can last many months due to the effects of the growth factors. There can be some variability in results and this will be in part due to the number and quality of platelets in the patient's blood.
For knee injections, improvements are expected to start within weeks. It is important to remember that we are stimulating change and recovery rather than simply trying to dull the pain in the way other treatment do.
How long do the results last?
Results from i-PRF therapy vary, but most will last up to around 18 months, and some up to 2 years.
To help preserve the results of the treatment, we recommend top-ups after about 12 months.
What do I need to do before and after treatment?
As the treatment harnesses your natural healing and regenerative capacity, avoiding known harmful behaviours – such as smoking and excessive UV exposure – is important following treatment.
We also advise you to avoid taking aspirin, non-steroidal medication (such as ibuprofen) and Vitamin E supplements for a few weeks following treatment, and always use high factor sun protection.
Is anyone not suitable for i-PRF treatment?
If any of the following situations or health conditions apply to you, you would not be suitable for PRP therapy.
– Pregnant or breast-feeding
– Undergoing anticoagulant therapy, such as warfarin
– Any medical condition having a significant effect on platelet function
– Haemodynamic instability
– Acute or chronic infections
If you have any questions about the treatment or would like a callback to discuss, please complete the form below.